Infection of the uterus without any detectable symptom.

Risk Factors

Abnormal births:

  • Assisted calvings
  • Induced calvings
  • Dead calves/stillbirths
  • Twins
  • Retained fetal membranes

Metabolic disorders:

  • Milk fever
  • Ketosis
  • Fatty liver syndrome
  • Displaced abomasum

Postpartum Uterine Disease in Cattle1

Definition Clinical signs

Acute systemic illness due to infection of the uterus with bacteria, usually within 10 days after parturition.
Two types:

  • “Thin-walled,” with copious discharge
  • “Thick-walled,” with little discharge
  • Fetid, red-brown watery uterine discharge
  • Pyrexia
  • In severe cases, reduced milk yield, dullness, inappetence or anorexia, elevated heart rate, and apparent dehydration

Infection of the uterus after 21 days or more post partum, not accompanied by systemic signs.

  • Purulent (>50% pus) or mucopurulent (approx. 50% pus, 50% mucus) uterine exudate
  • No signs of clinical illness

Endometrial inflammation of the uterus, usually determined by cytology, in the absence of purulent material in the vagina.

  • Presence of >18% neutrophils in uterine cytology
  • Samples collected 20-33 days post partum
  • >10% neutrophils at 34-47 days post partum
  • Usually the main symptom is repeat breeding

It occurs during the same period as subacute and chronic endometritis.

  • Accumulation of purulent or mucopurulent material within the uterine lumen and distension of the uterus, in the presence of an active CL


In most cows uterine involution is a septic process. Bacteria are found to invade the uterus during the first two weeks post partum. Whether the uterus overcomes this infection depends on the number and virulence of the bacteria present, condition of the uterus, and the quality of natural defense mechanisms.

In the course of a normal postpartum, a cow cures a uterine infection by rapid involution of the uterus and cervix, discharge of uterine contents and mobilization of natural host defense, including mucus, antibodies and phagocytic cells.

The uteri of cows with periparturient problems are larger and require three to five days longer for involution than the uteri of normal cows. These cows will have a reduced ability to control uterine infections.

If parturition is prolonged or assistance is needed2, the chances for bacterial infection increase.

  • Excessive stretching of the uterus (e.g., hydrops allantois or twins)
  • Traumatic injury of genitals during dystocia or obstetric manipulations
  • Metabolic disorders

The concomitant high prevalence of T. pyogenes and Gram-negative anaerobic bacteria seems to be related to the severity of endometritis and suggests a synergistic action between the bacteria.

synergistic action between the bacteria in endometritis

Clinical Diagnosis

  • Clinical history
  • Visual inspection (discharge)
  • Rectal examination
  • Vaginoscopy: More accurate but less practical method than rectal palpation or vaginal inspection for determining the presence of subacute and chronic endometritis
  • Use of Metricheck® device


Intra-uterine treatment with antibiotics can be effective if:

  • The antibiotic has the right spectrum for the main pathogens
  • The concentration at the site of inflammation is high enough
  • The antibiotic does not inhibit the natural defense of the uterus

Administrating prostaglandin F2α or its analogues at normal luteolytic doses is the treatment of choice for pyometra in cattle. No intrauterine treatment is recommended in conjunction with the prostaglandin3.


  1. Sheldon, I.M., Lewis, G.S., LeBlanc, S., Gilbert, R.O. 2006. Defining postpartum uterine disease in cattle. Theriogenology. 65(8):1516-30.
  2. Dohmen, M.J.W., Lohuis, J.A.C.M., Huszenicaza, G.Y., Nagy, P., Gacs, M. 1995. The relationship between bacteriological and clinical findings in cows with sub acute / chronic endometritis. Theriogenology, 43; 1379-1388.
  3. Gilbert, R.O. https://www.msdvetmanual.com/reproductive-system/metritis-in-large-animals/pyometra-in-large-animals. MSD Veterinary Manual.